NANOPARTICLE-BASED CONTRAST AGENTS FOR DIAGNOSTIC IMAGING Russian patent published in 2014 - IPC A61K49/04 A61K49/18 B82B3/00 B82Y5/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a nanoparticle-based contrast agent, where the nanoparticles contain a core whose surface is silicon dioxide free and a coating bound to the surface of the core and contains a silane-functionalised zwitterionic group. In one version, the nanoparticle does not contain a ligand which facilitates directed delivery. In another version, the nanoparticle contains a ligand which facilitates directed delivery, wherein the zwitterionic group and the ligand which facilitates directed delivery are not identical. The invention also relates to methods of producing said nanoparticles, a contrast agent composition containing a plurality of nanoparticles and use of the nanoparticles as a diagnostic agent.

EFFECT: invention relates to methods of using a composition which contains a plurality of said nanoparticles for X-ray imaging, computed tomography (CT) or magnetic resonance imaging (MRI), where the method includes administering the composition to a subject and imaging the subject using a diagnostic device.

23 cl, 2 tbl, 6 dwg