PREPARATION OF EXTREMELY SMALL AND UNIFORM-SIZED, IRON OXIDE-BASED PARAMAGNETIC OR PSEUDO-PARAMAGNETIC NANOPARTICLES AND MRI T1 CONTRAST AGENTS USING SAME Russian patent published in 2015 - IPC A61K49/08 A61K49/04 A61K47/02 A61K47/48 A61K9/16 

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing paramagnetic iron oxide nanoparticles. The disclosed method includes reacting an iron complex having iron as a central atom and a carboxylate group having 10 to 22 carbon atoms which is bonded to the central atom in a ligand form; a C10-C22 fatty acid and a C10-C22 aliphatic alcohol or C10-C22 aliphatic amine to obtain iron oxide nanoparticles. The iron oxide nanoparticles are obtained by raising the temperature from room temperature to 200 to 250°C with at a rate of 5°C/min or higher, and conducting the reaction at 200 to 250°C for 5 to 60 min.

EFFECT: invention enables to obtain iron oxide nanoparticles having a size of 4nm or less, which can be used as a MRI T1 contrast agent.

7 cl, 1 tbl, 25 dwg, 31 ex