NANOPARTICLE CONTAINING ITS MAGNETIC RESONANCE IMAGING CONTRAST AGENT AND LIGAND COMPOUND Russian patent published in 2022 - IPC A61K49/10 A61K49/18 C07C309/14 B82Y5/00 B82Y30/00 

Abstract RU 2767430 C2

FIELD: nanotechnology.

SUBSTANCE: invention relates to a nanoparticle used as a contrast agent for magnetic resonance imaging. Nanoparticle contains: metal-containing particle containing iron oxide; and a ligand which is bonded to a metal atom on the surface of the metal-containing particle and is represented by formula (3), where m is integer from 1 to 4, Me is methyl and the dashed line is a coordination bond with a metal atom on the surface of a metal-containing particle. Also disclosed is a contrast agent for magnetic resonance imaging, (3,4-dihydroxyphenyl)(dimethyl)(3-sulphonate propyl)ammonium and its use for producing a nanoparticle.

.

EFFECT: invention enables to obtain (i) a novel nanoparticle, (ii) a magnetic resonance imaging contrast agent containing it, in particular, a positive contrast agent having good relaxation, and (iii) a novel ligand compound used to produce a nanoparticle.

11 cl, 6 dwg, 7 ex

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RU 2 767 430 C2

Authors

Miyajima, Daigo

Takeuchi, Toshiaki

Sim, Seunghyun

Aida, Takuzo

Aoki, Ichio

Dates

2022-03-17Published

2018-06-27Filed