FIELD: chemistry; pharmaceutics.
SUBSTANCE: group of inventions relates to a combined lipid-polymer drug delivery system and a method for production thereof. Proposed delivery system is a complex of a liposomal form of a hydrophobic antibacterial compound with a logP value of not less than 4.0, selected from rifampicin, rapamycin or beta-caryophyllene, and a polymer conjugate of chitosan with molecular weight of 5–120 kDa with an inclusion complex of a β-cyclodextrin derivative, such as 2-hydroxypropyl-β-cyclodextrin or mono-(6-(hexamethylenediamine)-6-deoxy)-β-cyclodextrin, and a hydrophilic antibacterial compound with a logP value of not more than −0.4, which is a medicinal compound of the fluoroquinolone series, wherein in said polymer conjugate chitosan is substituted at the amino group with β-cyclodextrin derivatives.
EFFECT: group of inventions provides controlled prolonged action of medicinal compounds with increased bioavailability.
6 cl, 3 dwg, 4 tbl, 3 ex
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