NEW HISTONE DEACETYLASE INHIBITOR CLASS Russian patent published in 2011 - IPC C07D295/10 C07D211/58 C07D295/18 C07D295/20 C07D295/22 C07D211/46 C07D213/54 A61K31/4468 A61K31/495 A61K31/5375 A61P35/00 

FIELD: medicine.

SUBSTANCE: invention refers to a compound of formula (I) where Q represents a bond, CH-NR³ R⁴, NR⁵ or oxygen atom; X represents CH or nitrogen atom; Y represents a bond, CH₂, oxygen atom or NR⁶; Z represents CH or nitrogen atom; R¹, R² represent, independently, hydrogen, halogen; R³, R⁴ represent, independently, hydrogen, (C₁-C₆)-alkyl; R⁵ represents hydrogen, (C₁-C₆)-alkyl, (CO)R⁷, SO₂- (C₁-C₆)-alkyl or benzyl; R⁶ represents hydrogen, (C₁-C₆)-alkyl; R⁷ represents (C₁-C₆)-alkyl, phenyl, benzyl, OR⁸ or NR9R10; R⁸ represents (C₁-C₆)-alkyl; R⁹ represents hydrogen, (C₁-C₆)-alkyl; R9 represents hydrogen, (C₁-C₆)-alkyl; R¹¹, R¹² represent, independently, hydrogen or (C₁-C₆)-alkyl; and to their pharmaceutically acceptable salts; provided when X represents nitrogen atom, Y cannot represent oxygen atom or NR⁶; and except for the compounds (E)-N-hydroxy-3-(4-{(E)-3-[4-(4-methylpiperazine-1-yl)phenyl]-3-oxopropenyl}phenyl) acrylamide; (E)-N-hydroxy-3-{4-[(E)-3-(4-moropholine-4-ylphenyl)-3-oxopropenyl] phenyl}acrylamide; (E)-3-(3-flour-4-[(E)-3-(4-morpholine-4-ylphenyl)-3-oxopropenyl]phenyl}-N-hydroxyacrylamide. Also, the invention refers to a method for producing the compounds of formula (I), to a pharmaceutical composition, as well as to application of one or more compounds of formula (I), (la), (lb), (Ic).

EFFECT: producing new biologically active compounds which exhibit histone deacetylase inhibitor activity.

21 cl, 53 ex, 10 tbl