FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing fluorine-containing tetraketones of general formula: 
, where I) R1=CHCH(CH3)2; R2=CH3; II)R1=CH2; R2=Ph III) R1=CHCH2CH3; R2=Ph, which can be used as synthons for producing their fluorine-containing aza- and thio-analogues, β-hydroxyketones, pyrazoles, isoxazoles, as well as biologically active substances. The method involves reacting a diester of perfluoro-dicarboxylic acid with an alkylketone in the presence of sodium hydride in the medium of an organic solvent. The diester of perfluoro-dicarboxylic acid used is dimethyl ester of perfluoro-dodecane dicarboxylic acid and the alkylketone used is: acetophenone, methyl isobutyl ketone or propyl phenyl ketone, and the process is carried out in the presence of a catalyst - dibenzo-24-crown-8 ester, in molar ratio diester of perfluoro-dicarboxylic acid: alkylketone: sodium hydride: catalyst equal to 1 : (2-3.5) : 1 : (0.00025-0.0005).
EFFECT: method enables to obtain desired products with high output in a single step.
1 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF SYNTHESIS OF FLUORINE-CONTAINING $$$-DIKETONES | 1995 |
|
RU2100345C1 |
| CHELATE-FORMING DIBENZO-CONTAINING FIVE-MEMBERED CYCLIC COMPOUNDS COMPRISING TWO SYMMETRIC BETA-DICARBONYL SUBSTITUTES WITH FLUORINATED RADICALS | 2005 |
|
RU2296756C2 |
| N-SPACER-CONTAINING 3,6-BIS-β-DICARBONYL-SUBSTITUTED CARBAZOLES WITH FLUORINATED SUBSTITUTES, FOR USE AS MARKERS AND COMPLEXONS | 2019 |
|
RU2709194C1 |
| SIMPLE DIETHERS AND A METHOD OF THEIR SYNTHESIS | 1989 |
|
RU2027695C1 |
| METHOD OF PRODUCING ADAMANTYL-CONTAINING PHENOL DERIVATIVES | 2011 |
|
RU2458904C1 |
| PARTICLES CONTAINING CALCIUM OR MAGNESIUM ACETYLACETONATE AND A METHOD FOR PREPARING THESE PARTICLES | 1998 |
|
RU2208021C2 |
| METHOD FOR PREPARING ADAMANTYL-CONTAINING NITRILES | 2003 |
|
RU2240310C1 |
| 3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES AS STARTING COMPOUNDS FOR PRODUCING CHELATE COMPLEXES THEREOF WITH COPPER (II) IONS AND METHOD OF PRODUCING 3-PHENOXYPHENYL-CONTAINING 1,3-DIKETONES | 2012 |
|
RU2475473C1 |
| METHODS FOR PREPARING COMPOUNDS OF ORTHO-NITROBENZONITRILE (VARIANTS) | 1999 |
|
RU2236399C2 |
| METHOD OF SYNTHESIS OF ADAMANTYL-CONTAINING β-DIKETONES AND KETOESTERS | 2000 |
|
RU2187493C1 |
