FIELD: medicine.
SUBSTANCE: for thrombin production measurement, a layer of said sample contacts with a fluorogenic substratum of thrombin where the thickness of said layer is 0.05 to 5 mm, while the surface area is 10 to 500 mm2. Further, the thrombin production environment in said sample is provided. It is followed by measuring the fluorescence emitted from the layer surface by a fluorescent group released by the fluorescent substratum as a result of an enzymatic action of produced thrombin on said fluorogenic substratum. Besides, the invention ensures a kit for measuring the thrombin activity in the sample.
EFFECT: higher measuring accuracy.
29 cl, 12 dwg, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR MEASURING THROMBIN ACTIVITY | 2010 |
|
RU2429488C1 |
| METHOD OF DETERMINING SPACE-TIME DISTRIBUTION OF PROTEOLYTIC ENZYME ACTIVITY IN HETEROGENEOUS SYSTEM, DEVICE FOR REALISING THEREOF AND METHOD OF DIAGNOSING HEMOSTASIS SYSTEM DISORDERS BY CHANGE OF SPACE-TIME DISTRIBUTION OF PROTEOLYTIC ENZYME ACTIVITY IN HETEROGENIC SYSTEM | 2011 |
|
RU2518247C2 |
| NOVEL COMPOUNDS POSSESSING ANTICOAGULANT FUNCTION, BASED ON THEM PHARMACEUTICAL COMPOSITIONS FOR TREATMENT OF THROMBOTIC CONDITIONS AND PLASMA-SUBSTITUTING SOLUTION FOR CORRECTION OF HYPERCOAGULATION DISORDERS IN HEMODILUTION | 2007 |
|
RU2353619C2 |
| HIGHLY-SELECTIVE INFESTIN 4-BASED INHIBITOR OF CONTACT ACTIVATION | 2013 |
|
RU2556116C2 |
| SOLUTION FOR CORRECTION OF PRIMARY HOMEOSTASIS DISORDER WITH PLASMA-SUBSTITUTING SOLUTIONS OF NOVEL COMPOSITION | 2005 |
|
RU2300385C1 |
| METHOD OF CONTROLLING ANTICOAGULANT THERAPY | 2012 |
|
RU2607658C2 |
| METHOD OF PRODUCING PLATELET-ENRICHED FIBRIN MATRIX OF VARIOUS SHAPES AND SIZES | 2023 |
|
RU2811233C1 |
| NOVEL CHEMILUMINESCENT SUBSTRATES FOR Xa FACTOR | 2019 |
|
RU2820234C2 |
| KIT FOR MEASUREMENT OF THROMBIN FORMATION IN SAMPLED PATIENT'S BLOOD OR PLASMA | 2005 |
|
RU2360970C2 |
| SERUM FRACTION OF THROMBOCYTE-ENRICHED FIBRIN | 2014 |
|
RU2711330C2 |
