FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to biotechnology, namely to obtaining infestin-4 mutants, and can be used for diagnostic purposes in the determination of characteristics of clotting of blood and its components. A polypeptide is characterised by a sequence of the infestin 4 mutant MutB SEQ ID NO: 1. The said sequence can have modifications outside inhibiting the loop part, which essentially preserve the activity of the said polypeptide. The polypeptide is used for the inhibition of contact activation in a tested sample of blood or its product in order to increase the time of the sample storage.
EFFECT: invention makes it possible to obtain the highly-selective inhibitor fXIIa, selectivity or activity of which is higher than in the native infestin-4 and Mut15.
25 cl, 7 dwg, 3 tbl, 4 ex
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