METHOD OF DETECTING THROMBINEMIA IN LARGE JOINT REPLACEMENT Russian patent published in 2011 - IPC G01N33/48 G01N33/53 

FIELD: medicine.

SUBSTANCE: for detecting thrombinemia associated with large joint replacement, on the 10^th-14^th postoperative day, patient's blood plasma is examined for the hemostasis system values: the concentrations of D-dimer, plasminogen and antithrombin III. A discriminator (Z) is calculated by formula: Z=4.3936-0.001×D-0.029×P+0.017×A, where D is the concentration of D-dimer (ng/ml FEU), P is the concentration of plasminogen (percentage of normal concentration), A is the concentration of antithrombin (percentage of normal concentration). If observing the value Z <0, high probability of preserving thrombinemia is diagnosed, and pharmacological antithrombotic prevention is recommended to be continued.

EFFECT: use of the declared method allows high-efficient determination of appropriateness of prolongation of a pharmacological antithrombotic prevention course following the large joint replacement.

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