NEUROTRYPSIN INHIBITORS Russian patent published in 2011 - IPC C07C311/64 A61K31/63 A61P21/00 A61P25/28 A61P19/00 A61P25/18 

Abstract RU 2424228 C2

FIELD: chemistry.

SUBSTANCE: invention describes a method of determining whether a compound is a neurotrypsin inhibitor, as well as a method of measuring catalytic activity of neurotrypsin, where the tested compound is incubated together with human or mouse neurotrypsin or a fragment of human or mouse neurotrypsin which contains a neurotrypsin protease domain, and with a complete length or soluble agrin, or agrin-C45, or a fluorescent protein, or a peptide containing agrin, agrin-C45, in an aqueous buffer solution at pH 7.5 and the number of agrin cleavages is measured.

EFFECT: improved properties.

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RU 2 424 228 C2

Authors

Zonderegger Peter

Khettver Shtefan

Bolliger Mark F.

Drajer Birgit

Kunts Beat

Ljusher Daniel'

Rajf Rajmond

Zales Zuzanne

Dates

2011-07-20Published

2006-03-29Filed