GENETIC NUCLEOTIDE SEQUENCES OF ARTIFICIALLY MODIFIED GDNF WITH DELETED pro-REGION, PRODUCT OF WHICH HAS IMPROVED PROPERTIES NEURAL INDUCTOR AND STIMULATOR OF FORMATION OF NEURAL PROCESSES, SUITABLE FOR THERAPY OF NEURAL INJURIES, ISCHEMIC STROKES AND NEURODEGENERATIVE DISEASES, EXPRESSION VECTOR, MODIFIED WITH GDNF Russian patent published in 2016 - IPC C12N15/12 C07K14/475 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Disclosed is cDNA of natural GDNF gene artificially modified by removal of pro-region, which in mammalian cells or tissues in standard vectors produces active specific GDNF. Invention also relates to an expression vector containing said cDNA, as well as to active specific GDNF encoded by said cDNA. During translation in cells and tissues said GDNF stimulates neural differentiation of stem and progenitor cells with formation of neural processes.

EFFECT: invention increases activity of GDNF as neural inductor and stimulator of formation of neural processes and can be used in therapy of neurodegenerative disorders, traumatic disorders of innervation as well as ischemic cerebral apoplexies of mammals, including humans.

3 cl, 13 dwg, 5 ex