FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing prasugrel hydrochloride of the formula:
,
with low content of "ОХТР", involving preparation of free prasugrel containing "ОХТР" from 2-silyloxy-5-(α-cyclopropylcarbonyl-2-fluorobenzyl)-4,5,6,7-tetrahydrothieno[3,2-c]pyridine, dissolving the obtained free prasugrel in an inert solvent and optionally adding hydrochloric acid in drops to the solution for reaction.
EFFECT: novel method of producing prasugrel with low content of impurities, specifically "ОХТР" by-product.
2 cl, 6 dwg, 1 tbl, 2 ex
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