FIELD: chemistry.
SUBSTANCE: invention relates to crystalline form of 6-[2-(methylcarbamoyl)phenylsulfanyl]-3-e-[2-(pyridin-2-yl)ethenyl]indazole, which can prove to be efficient in treatment of abnormal growth of cells. Said crystalline form is in fact pure polymorph of XLI form and has powder X-ray image including peak at diffraction angle (2θ) 6.0±0.1 and additionally including, at least, one peak at diffraction angle (2θ), selected from 11.5±0.1, 21.0±0.1 and 26.9±0.1. Said crystalline form can also include peaks at diffraction angle (2θ) 11.9±0.1, 15.6±0.1, 16.2±0.1, 16.5±0.1, 22.8±0.1 and 23.1±0.1. Peaks on powder X-ray image are measured with application of CuKα radiation (
=1,54056 Å). In addition said crystalline form has NMR spectrum in solid body, including 13C chemical shifts at 150.1±0.2 and 27.5±0.2 ppm.
EFFECT: crystalline form possesses improved light resistance and has more correct shape of crystals Invention also relates to pharmaceutical composition, which includes said crystalline form.
6 cl, 16 dwg, 15 tbl, 7 ex
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