METHOD OF ESTIMATING ADEQUACY OF TREATING PATIENTS WITH MYASTHENIA Russian patent published in 2011 - IPC A61B1/00 A61K31/14 A61P21/00 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to neurology and deals with estimation of adequacy of treating patients with myasthenia. For this purpose before and after thymectomy motorograms of esophagus are registered with application of gastrointestinal monitor GIM-1. Into esophagus lumen introduced is hollow probe with ruler from 0 to 60 cm marking, which contain photosensor, whose position is installed under control of roentgenoscope in cervical part, upper and medium third of thoracic part by probe marking. In each said position of photosensor motor activity of water swallow passing is registered. Recording is repeated 30 minutes after introduction of anti-cholinesterase preparation, comparing motograms and determining change of esophagus motor activity after introduction of preparation. On the 1-st and 5-th day after thymectomy determined is adequate therapeutic dose of anti-cholinesterase preparation after operation, preventing myasthenic and cholinergic crises. In case if esophagus motor activity after medication introduction improves, dose is increased, if there are no changes dose remains the same, if motor activity decreases, dose is reduced. 6 months and a year after thymectomy motograms are compared with motorgrames obtained immediately after operation and if motor activity has improved and changes have decreased after anti-cholinesterase medication introduction, conclusion about adequacy of performed operation is made.

EFFECT: method ensures estimation of thymectomy efficiency in each particular case and makes it possible to correct algorithm of patient's treatment after operation.

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