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2 426 174

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IPC

G09B23/28(2006-01-01)

A61K38/18(2006-01-01)

A61P9/10(2006-01-01)

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Application

2010112037/14, 2010-03-29

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Start date

2010-03-29

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Actual filing date

2010-03-29

(45)

Published

2011-08-10

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Inventor

Pokrovskij Mikhail VladimirovichLazarenko Viktor Anatol'EvichKolesnik Inga MikhajlovnaPokrovskaja Tat'Jana Grigor'EvnaDanilenko Ljudmila MikhajlovnaKorolev Anton Evgen'EvichKorokin Mikhail ViktorovichRagulina Vera AlekseevnaGudyrev Oleg SergeevichBezhin Aleksandr IvanovichLopatin Dmitrij VladimirovichEgorova Ekaterina OlegovnaNovikov Oleg OlegovichArustamova Anna AleksandrovnaNarykov Roman AleksandrovichDenisjuk Tat'Jana AlekseevnaTitareva Ljudmila ViktorovnaSytnik Mikhail VladimirovichGureev Vladimir VladimirovichLosenok Polina IgorevnaSarojan Karen VanushevichKorokina Lilija ViktorovnaLoktionova Inna LeonidovnaMal'Tseva Natal'Ja ViktorovnaOrlova Anzhelika Jur'Evna

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet Federal'Nogo Agentstva Po Zdravookhraneniju I Sotsial'Nomu Razvitiju"

METHOD OF PHARMACOLOGICAL CORRECTION OF EXTREMITY ISCHEMIA INCLUDING IN L-NAME INDUCED NITROGEN OXIDE DEFICIENCY Russian patent published in 2011 - IPC G09B23/28 A61K38/18 A61P9/10 

Abstract RU 2426174 C1

FIELD: medicine.

SUBSTANCE: extremity ischemia is modelled by removing a portion of a great vessel, including with simultaneous additional modelling of nitrogen oxide (NO) deficiency by intraperitoneal introduction of a NO synthesis blocker N-nitro-L-arginine of methyl ester (L-NAME) 25 mg/kg daily for 7 days. In both cases, the ischemia is corrected by subcutaneous introduction of recombinant erythropoein 50 IU/kg for the first, third and fifth days of experiment.

EFFECT: effective ischemia treatment in experiment ensured by improved extremity microcirculation.

1 ex, 1 tbl

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RU 2 426 174 C1

Authors

Pokrovskij Mikhail Vladimirovich

Lazarenko Viktor Anatol'Evich

Kolesnik Inga Mikhajlovna

Pokrovskaja Tat'Jana Grigor'Evna

Danilenko Ljudmila Mikhajlovna

Korolev Anton Evgen'Evich

Korokin Mikhail Viktorovich

Ragulina Vera Alekseevna

Gudyrev Oleg Sergeevich

Bezhin Aleksandr Ivanovich

Lopatin Dmitrij Vladimirovich

Egorova Ekaterina Olegovna

Novikov Oleg Olegovich

Arustamova Anna Aleksandrovna

Narykov Roman Aleksandrovich

Denisjuk Tat'Jana Alekseevna

Titareva Ljudmila Viktorovna

Sytnik Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Losenok Polina Igorevna

Sarojan Karen Vanushevich

Korokina Lilija Viktorovna

Loktionova Inna Leonidovna

Mal'Tseva Natal'Ja Viktorovna

Orlova Anzhelika Jur'Evna

Dates

2011-08-10—Published

2010-03-29—Filed

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