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2 462 766

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IPC

G09B23/28(2006-01-01)

A61K38/18(2006-01-01)

A61P9/14(2006-01-01)

A61P15/16(2006-01-01)

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Application

2011116378/14, 2011-04-25

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Start date

2011-04-25

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Actual filing date

2011-04-25

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Published

2012-09-27

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Inventor

Pokrovskij Mikhail VladimirovichGureev Vladimir VladimirovichPoljanskaja Oksana SergeevnaMal'Tseva Natal'Ja ViktorovnaKorokina Lilija ViktorovnaPokrovskaja Tat'Jana Grigor'EvnaGureeva Elena Gennad'EvnaKochkarov Vladimir IskhakovichBondarenko Evgenija Valer'EvnaDanilenko Ljudmila MikhajlovnaZhernakov Evgenij VladislavovichGolovchenko Il'Ja OlegovichKhadieva Taisija AbduladirovnaPakhomov Sergej PetrovichDenisjuk Tat'Jana AlekseevnaKotel'Nikova Lilija ViktorovnaAlekhin Sergej AleksandrovichAlekhina Valerija Valer'EvnaKorokin Mikhail ViktorovichGudyrev Oleg SergeevichBelous Aleksandr SergeevichTsybul'Skij Igor' Valer'Evich

(73)

Holder

Gosudarstvennoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Meditsinskij Universitet" Ministerstva Zdravookhranenija I Sotsial'Nogo Razvitija Rossijskoj Federatsii

METHOD FOR ENDOTHELIAL DYSFUNCTION CORRECTION BY RECOMBINANT ERYTHROPOIETIN IN ADMA-LIKE GESTOSIS MODEL Russian patent published in 2012 - IPC G09B23/28 A61K38/18 A61P9/14 A61P15/16

Abstract RU 2462766 C1

FIELD: medicine.

SUBSTANCE: method involves simulating gestosis in Wistar rats by the daily intraperitoneal introduction of L-nitro-arginine-methyl ester 25 mg/kg for 14th to 20th day of pregnancy. The simulated pathology is corrected by the subcutaneous introduction of recombinant erythropoietin 50 IU/kg on the 7^th, 10^th, 13^th, 16^th, 19^th day of pregnancy.

EFFECT: method provides correction of systemic endothelial dysfunction accompanying gestosis in the specific experimental environment.

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RU 2 462 766 C1

Authors

Pokrovskij Mikhail Vladimirovich

Gureev Vladimir Vladimirovich

Poljanskaja Oksana Sergeevna

Mal'Tseva Natal'Ja Viktorovna

Korokina Lilija Viktorovna

Pokrovskaja Tat'Jana Grigor'Evna

Gureeva Elena Gennad'Evna

Kochkarov Vladimir Iskhakovich

Bondarenko Evgenija Valer'Evna

Danilenko Ljudmila Mikhajlovna

Zhernakov Evgenij Vladislavovich

Golovchenko Il'Ja Olegovich

Khadieva Taisija Abduladirovna

Pakhomov Sergej Petrovich

Denisjuk Tat'Jana Alekseevna

Kotel'Nikova Lilija Viktorovna

Alekhin Sergej Aleksandrovich

Alekhina Valerija Valer'Evna

Korokin Mikhail Viktorovich

Gudyrev Oleg Sergeevich

Belous Aleksandr Sergeevich

Tsybul'Skij Igor' Valer'Evich

Dates

2012-09-27—Published

2011-04-25—Filed