FIELD: medicine.
SUBSTANCE: invention relates to obtaining and application of staphylococcal anatoxin-vaccine for prevention and treatment of animal diseases of staphylococcal etiology. Method by invention includes growing staphylococci on synthetic nutritional medium with further autoclaving of obtained suspension of microorganisms. After that, detoxication of obtained complex of staphylococcal exo-, endo- and superenterotoxins is performed by two detoxicators: first by 0.2-0.3% glutardehyde solution during 3-5 days at 40-42°C, then by 0.2% ethonium solution or 0.15-0.25% solution of alkylmethylbenzyl ammonium during 3-5 days at 40-42°C. After that, target product is sorbed on aluminium hydroxide in dose 3-5 mg/ml.
EFFECT: method application makes it possible to increase protective and therapeutic efficiency and safety of anatoxin-vaccine.
1 tbl, 3 ex
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