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2 426 792

(13)

(51)

IPC

C12P33/08(2006-01-01)

(21) (22)

Application

2008133472/10, 2007-01-16

(24)

Start date

2007-01-16

(22)

Actual filing date

2007-01-16

(45)

Published

2011-08-20

(72)

Inventor

Messinger JozefTole Genrikh-KhubertRashe Khajnts-Khel'MerShmidt Mikhaehl'Khakala Jukha

(73)

Holder

Zol'Vaj Farmas'Jutiklz Gmbkh

METHOD OF PREPARING 11-BETA-HYDROXY-9-BETA, 10-ALPHA STEROIDS WITH USING AMYCOLATOPSIS MEDITERRANEI CELLS Russian patent published in 2011 - IPC C12P33/08

Abstract RU 2426792 C2

FIELD: medicine.

SUBSTANCE: what is declared is application of bacterial strains of Amycolatopsis mediterranei species for microbiological transformation of 9β,10α-steroids of general formula (I) into their relevant 11β-hydroxyl analogues. Also, presented is a new bacterial strains Amycolatopsis mediterranei DSM 17416 for microbiological transformation of 9β,10α-steroids of general formula (I) into their relevant 11β-hydroxyl analogues. A method of transformation of 9β,10α-steroids into their relevant 11β-hydroxyl derivatives. The method involves contact of the compounds of formula (I) in a fermentative medium with the Amycolatopsis mediterranei bacterium. Also, the 11β-hydroxy-9β,10α-steroid compounds of formula (V) are declared.

EFFECT: method improvement.

20 cl, 3 tbl

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RU 2 426 792 C2

Authors

Messinger Jozef

Tole Genrikh-Khubert

Rashe Khajnts-Khel'Mer

Shmidt Mikhaehl'

Khakala Jukha

Dates

2011-08-20—Published

2007-01-16—Filed