FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and concerns oligonucleotide dosing. Substance of the invention involves application of at least one oligonucleotide of the sequence SEQ ID NO:5 for preparing a pharmaceutical preparation for prevention and/or treatment of a malignant tumour and/or metastases in a mammal, and said oligonucleotide is hybridised with a matrix RNA of TgF-beta2 gene and where said preparation contains said oligonucleotide in the concentration approximately 5 mcM to approximately 25 mcM.
EFFECT: lower preparation dose.
14 cl, 12 ex, 5 tbl, 5 dwg
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