VACCINE FOR ROTA-, CORONAVIRAL INFECTION AND CATTLE COLIBACILLOSIS Russian patent published in 2019 - IPC A61K39/15 A61K39/215 A61K39/108 A61P31/00 

FIELD: veterinary medicine.

SUBSTANCE: invention refers to veterinary science, namely to virology, and can be used to produce a vaccine for rota-, coronaviral infection and cattle colibacillosis. Vaccine as an active substance contains a mixture of inactivated suspension of rotavirus strain RM, family Reoviridae, genus Rotavirus, inactivated suspension of the coronavirus KL-2 strain of the Coronaviridae family, of the genus Coronavirus, with activity of each of viral strains 10^5.5 - 10^6.5 TCDD₅₀ in cm³ a vaccine grown in a transplantable cell culture of MDVK or LEC, and adhesive antigens K99, F41, Att25 of Escherichia coli bacteria; purification of adhesive antigens K99, F41, Att25 of Escherichia coli bacteria taken in equal ratio (1:1:1), with concentration 50–100 ml of microbial cells in 1 cm³ vaccines are carried out with concentration of the solution of phosphate-urea buffer increased to 1.5–3.0 M.

EFFECT: using the given invention enables to obtain an associated trivalent vaccine exhibiting high immunogenicity in association with adhesive Escherichia coli strains.

1 cl, 4 ex, 4 tbl