METHOD OF PREPARING BIOLOGICALLY ACTIVE COATING Russian patent published in 2011 - IPC A61L27/32 A61L27/34 A61F2/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine. What is described is a method of preparing a biologically active coating of pore size 80 mcm and more, exposed porosity up to 45% which consists in the fact that a polymer solution is prepared, then hydroxyapatite powder is added, mixed to a homogenised state, dried with poly(vinylidene fluoride-co-tetrafluorethylene) used, mixed acetone and ethyl acetate used as a solvent; hydroxyapatite powder is preprocessed in a ball mill, then the prepared copolymer solution and a hydroxyapatite powder dispersion are mixed in a ball mill; the prepared mixture is reduced to viscosity to put the given mixture on prostheses. Poly(vinylidene fluoride-co-tetrafluorethylene) and the mixture solvent are taken in the ratio, wt %: poly(vinylidene fluoride-co-tetrafluorethylene) - 10-20 and mixture solvent - 80-90; acetone and ethyl acetate in the ratio, wt %: acetone - 50-70 and ethyl acetate - 30-50; hydroxyapatite powder and butyl acetate in the ratio, wt %: hydroxyapatite powder dispersion and copolymer solution in the ratio, wt %: hydroxyapatite powder dispersion - 30-70 and copolymer solution - 30-70.

EFFECT: higher osteoinductive properties up to 70-75%, provided adhesion to a metal substratum not less than 10 MPa, higher elasticity not less than 4 mm.

5 cl, 1 tbl, 3 ex