METHOD OF TREATING SIGNET RING CELL STOMACH CARCINOMA Russian patent published in 2011 - IPC A61K35/14 A61K31/513 A61P35/00 

FIELD: medicine.

SUBSTANCE: intraoperationally introduced is fluoruracyl in dose 1000 mg/m and leukovorine in dose 100 mg/m after incubation with 100 ml of ozonised 400 mcg/l of autoblood intravenously. Oxaliplatin in dose 100 mg/m² with 50 ml of ozonised 1000 mcg/l physiological solution is introduced into left gastric artery. Exposition of medications is 30 min. Gastrectomy is performed. After 7 days blood is sampled from patient in amount 100 ml in sterile vial with glugicir. Blood is bubbled. Concentration of ozone in ozone-oxygen mixture is 400 mcg/l. 100 mg/m² of oxaliplatine are added and re-infused to patient intravenously, in drops. Next day 1000 mg/l of fluoruracyl and 100 mg/m² of leukovorine are introduced successively intravenously, in drops with 100 ml of ozonised 400 mcg physiological solution. Treatment is repeated two times more with 3 week interval.

EFFECT: method makes it possible to prolong remission terms.

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