FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing a compound of general formula 1
by reacting a substituted indole derivative I'
with a heteroarylzinc halide of formula: 
or a diheteroarylzinc of formula: 
where: L denotes Br, Cl; R denotes (C1-C8)alkyl; X denotes (C3-C8)cycloalkyl; Y denotes a 6-member heteroaryl with one or two N atoms; Z denotes HO2C-, (C1-C8)alkyl-O2C-, (C1-C6)alkyl-HNC(O)-, 
or 
in the presence of a Pd metal catalyst, a ligand selected from Ph3P, n-Tol3P, Cy3P, tpet-Bu3P, Cy2P(Ph-Ph), dppfh and dppb, in a solvent selected from tetrahydrofuran, dimethylformamide, N-methylpyrrolidone or any other combination thereof, at temperature between ambient temperature and 100°C. The invention also describes intermediate compounds.
EFFECT: high efficiency of the method.
12 cl, 3 dwg, 2 tbl, 4 ex
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