TREATMENT OF INTERFERON-RELATED DEVELOPMENTAL REGULATOR 1 (IFRD1) ASSOCIATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO IFRD1 Russian patent published in 2017 - IPC C12N15/113 A61K31/7088 C12N15/63 C12Q1/68 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry. Described synthetic oligonucleotide with length from 19 to 30 nucleotides, containing at least one modification, wherein said at least one modification selected from: at least one modified sugar residue; at least one modified internucleotide linkage; at least one modified nucleotide; and their combinations. Note here that said oligonucleotide specifically hybridized with natural antisense polynucleotide IFRD1 gene and has the sequence, at least at 90 % identical to sequence, reverse complementary by section within nucleotides 1-740 of sequence SEQ ID NO: 2, or 1-418 sequence of SEQ ID NO: 3, or 1-540 sequence of SEQ ID NO: 4, or 1-546 sequence of SEQ ID NO: 5, or 1-429 sequence of SEQ ID NO: 6, or 1-429 sequence of SEQ ID NO: 7, or has the sequence, at least at 90 % identical to the section of the sequence SEQ ID NO: 1. Invention also relates to use of said antisense oligonucleotide for treatment of diseases and disorders associated with expression IFRD1.

EFFECT: invention extends the range of agents for treatment diseases and disorders associated with expression IFRD1.

32 cl, 1 dwg, 1 tbl, 2 ex