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2 434 005

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IPC

C07D265/36(2006-01-01)

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Application

2010143297/04, 2010-10-25

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Start date

2010-10-25

(22)

Actual filing date

2010-10-25

(45)

Published

2011-11-20

(72)

Inventor

Charushin Valerij NikolaevichGorbunov Evgenij BorisovichRusinov Gennadij LeonidovichLikholobov Vladimir AleksandrovichRodionov Vladimir Aleksandrovich

(73)

Holder

Rossijskaja Federatsija, Ot Imeni Kotoroj Vystupaet Ministerstvo Obrazovanija I Nauki Rossijskoj FederatsiiUchrezhdenie Rossijskoj Akademii Nauk Institut Organicheskogo Sinteza Im. I.Ja. Postovskogo Ural'Skogo Otdelenija Ran

METHOD OF PRODUCING 7,8-DIFLUORO-2,3-DIHYDRO-3-METHYL-4H-1,4-BENZOXAZINE Russian patent published in 2011 - IPC C07D265/36

Abstract RU 2434005 C1

FIELD: chemistry.

SUBSTANCE: invention relates to a method of producing 7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine. The method is realised via hydrogenation of 2-acetonyloxy-3,4-difluoronitrobenzene with hydrogen in the presence of palladium on a Sibunit carbon support as a catalyst. The process takes place in isopropyl alcohol at pressure 3.0-3.5 bars and temperature 30-50°C. Extraction and drying of the desired product is carried out by successively turning it into 7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine hydrochloride by treating with 1.5-1.7-fold excess hydrochloric acid in a water-toluene solution and then into free 7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine by treating 7,8-difluoro-2,3-dihydro-3-methyl-4H-1,4-benzoxazine hydrochloride with an aqueous alkaline solution and vacuum distillation.

EFFECT: improved method of obtaining a composition with high content of basic substance.

5 ex

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RU 2 434 005 C1

Authors

Charushin Valerij Nikolaevich

Gorbunov Evgenij Borisovich

Rusinov Gennadij Leonidovich

Likholobov Vladimir Aleksandrovich

Rodionov Vladimir Aleksandrovich

Dates

2011-11-20—Published

2010-10-25—Filed