METHOD OF PRODUCING ETHYL ETHER OF 3-OXO-3-(2,6-DICHLOROPYRIDIN-3-YL) PROPANOIC ACID Russian patent published in 2011 - IPC C07D213/79 

Abstract RU 2435758 C1

FIELD: chemistry.

SUBSTANCE: invention relates to synthesis of 1,3-dicarbonyl compounds and specifically to a method of producing ethyl ether of 3-oxo-3-(2,6-dichloropyridin-3-yl) propanoic acid of formula: . The method involves acylation of potassium 3-oxo-3-ethoxypropanoate with 2,6-dichloronicotinoyl chloride in the presence of anhydrous solvent, ethylamine and magnesium chloride, followed by treatment of the reaction mass with aqueous hydrochloric acid solution and extraction of the end product, characterised by that the solvent used is ethylacetate, where the molar ratio 2,6-dichloronicotinoyl chloride: potassium 3-oxo-3-ethoxypropanoate is equal to 1:1.4-1.6.

EFFECT: high technological effectiveness of synthesis, as well as high output and purity of the disclosed compound.

1 cl, 3 ex

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RU 2 435 758 C1

Authors

Novakov Ivan Aleksandrovich

Orlinson Boris Semenovich

Navrotskij Maksim Borisovich

Gerasimov Evgenij Nikolaevich

Jablokov Aleksandr Sergeevich

Shinkarenko Ekaterina Arkad'Evna

Dates

2011-12-10Published

2010-07-19Filed