FIELD: chemistry.
SUBSTANCE: invention relates to synthesis of 1,3-dicarbonyl compounds and specifically to a method of producing ethyl ether of 3-oxo-3-(2,6-dichloropyridin-3-yl) propanoic acid of formula: . The method involves acylation of potassium 3-oxo-3-ethoxypropanoate with 2,6-dichloronicotinoyl chloride in the presence of anhydrous solvent, ethylamine and magnesium chloride, followed by treatment of the reaction mass with aqueous hydrochloric acid solution and extraction of the end product, characterised by that the solvent used is ethylacetate, where the molar ratio 2,6-dichloronicotinoyl chloride: potassium 3-oxo-3-ethoxypropanoate is equal to 1:1.4-1.6.
EFFECT: high technological effectiveness of synthesis, as well as high output and purity of the disclosed compound.
1 cl, 3 ex
Title | Year | Author | Number |
---|---|---|---|
METHOD OF OBTAINING ETHYL ESTER OF 2-METHYL-3-OXO-4-(2,6-DIFLUOROPHENYL)PENTANOIC ACID | 2012 |
|
RU2490252C1 |
DERIVATIVES OF 4,1-BENZOXAZEPINE, PHARMACEUTICAL COMPOSITION, METHOD OF INHIBITION OF ACTIVITY OF SQUALENE SYNTHETASE IN MAMMALS, METHOD OF INHIBITION OF FUNGI GROWTH IN MAMMALS | 1993 |
|
RU2145603C1 |
METHOD OF OBTAINING 2-OXO-4-CYANO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDES | 2011 |
|
RU2475480C1 |
DERIVATIVES OF ISOINDOLONE AS (3 AR, 7 AR)- OR (3 ARS, 7 ARS)-FORMS OR THEIRS MIXTURES OR THEIRS HYDROCHLORIDES, WHICH ARE ANTAGONISTS OF COMPOUND P | 1990 |
|
RU2012559C1 |
METHOD OF PRODUCING ETHYL 5-METHYL-3-(3-PHENOXYPHENYL)-1-PHENYL-1H-PYRAZOLYL-4-CARBOXYLATE | 2015 |
|
RU2582127C1 |
DERIVATIVES OF PYRIDONE CARBOXYLIC ACID, METHODS OF THEIR SYNTHESIS, ANTITUMOR AGENT AND PHARMACEUTICAL COMPOSITION | 1995 |
|
RU2151770C1 |
HETEROCYCLIC NITROGEN-CONTAINING DERIVATIVES OF CARBOXYLIC ACID, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION | 1993 |
|
RU2124503C1 |
METHOD OF SYNTHESIS OF 3-PROPENYLCEPHEME DERIVATIVES OR THEIRS PHARMACEUTICALLY ACCEPTABLE SALTS | 1987 |
|
RU2010796C1 |
METHOD FOR PREPARING 4-SUBSTITUTED ALKYL-3-OXOBUTANOATES | 2003 |
|
RU2254328C1 |
METHOD OF PRODUCING AMIDES, THEIR DIASTEREOMERS, RACEMATES OR THEIR ACID-ADDITIVE SALTS | 0 |
|
SU1614759A3 |
Authors
Dates
2011-12-10—Published
2010-07-19—Filed