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2 475 480

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IPC

C07D215/16(2006-01-01)

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Application

2011140916/04, 2011-10-07

(24)

Start date

2011-10-07

(22)

Actual filing date

2011-10-07

(45)

Published

2013-02-20

(72)

Inventor

Lipin Konstantin VladimirovichEremkin Aleksej VladimirovichNasakin Oleg Evgen'EvichFedoseev Sergej VladimirovichErshov Oleg VjacheslavovichKajukov Jakov SergeevichBelikov Mikhail Jur'Evich

(73)

Holder

Federal'Noe Gosudarstvennoe Bjudzhetnoe Obrazovatel'Noe Uchrezhdenie Vysshego Professional'Nogo Obrazovanija Gosudarstvennyj Universitet Imeni I.N. Ul'Janova"

METHOD OF OBTAINING 2-OXO-4-CYANO-1,2-DIHYDROPYRIDINE-3-CARBOXAMIDES Russian patent published in 2013 - IPC C07D215/16

Abstract RU 2475480 C1

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to field of organic chemistry, namely to method of obtaining 2-oxo-4cyano-1,2-dihydropyridine-3-carboxamides of general formula , where R¹+R²=(CH₂)₄, (CH₂)₅, (CH₂)₆, (CH₂)₂CH(CH₃)CH₂, (CH₂)₂CH[C(CH₃)₃]CH₂, which lies in the following: respective 4-oxoalkane-1,1,2,2-tetracarbonitryl is dissolved in inert organic solvent, 25 mmole of water per 1 mmole of initial component are added, after which reaction mass is heated for 1.5-2 hours at 75-80°C until target product is formed.

EFFECT: described is method of obtaining novel compounds, which can find application as medications for prevention and treatment of pellagra, hyperlipemia, spasm of peripheral vessels, stenocardia, as well as central nervous system stimulators.

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RU 2 475 480 C1

Authors

Lipin Konstantin Vladimirovich

Eremkin Aleksej Vladimirovich

Nasakin Oleg Evgen'Evich

Fedoseev Sergej Vladimirovich

Ershov Oleg Vjacheslavovich

Kajukov Jakov Sergeevich

Belikov Mikhail Jur'Evich

Dates

2013-02-20—Published

2011-10-07—Filed