ENZYME PREPARATION OF THROMBOLYTIC AND FIBRINOLYTIC ACTION MADE OF BASIDIUM FUNGI OF Coprinus Russian patent published in 2011 - IPC C12N9/58 C12R1/645 

FIELD: medicine.

SUBSTANCE: preparation of thrombolytic and fibrinolytic action is produced by submerged cultivation on a liquid nutrient medium, of a strain of basidium fungus of Coprinus lagopides TI-12, or Coprinus lagopides TI-32, or Coprinus lagopides TI-33 stored in the high basidium fungi culture collection of the microbiological synthesis technology department of the St.-Petersburg State Technical University, separation of a mycelial biomass from a native solution. The prepared solution is concentrated by ultrafiltration with using a semipermeable membrane with a nominal molecular-mass rejection limit up to 20 kDa followed by cool dehumidification in the mode suitable for protein compounds. The invention has allowed detecting Coprinus lagopides from basidium fungi of Coprinus exhibiting high thrombolytic and fibrinolytic activity.

EFFECT: preparation in the low concentration shows a high level of thrombolytic and fibrinolytic activity in vivo.

2 dwg, 4 tbl, 5 ex