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(19)

RU

(11)

2 439 065

(13)

C2

(51)

IPC

C07D243/14(2006-01-01)

C07D401/06(2006-01-01)

C07D401/14(2006-01-01)

C07D403/06(2006-01-01)

C07D405/06(2006-01-01)

C07D413/12(2006-01-01)

C07D471/10(2006-01-01)

A61K31/551(2006-01-01)

A61P9/10(2006-01-01)

(21) (22)

Application

2008145220/04, 2007-04-11

(24)

Start date

2007-04-11

(22)

Actual filing date

2007-04-11

(45)

Published

2012-01-10

(72)

Inventor

Ehbi IogannesGrin L'JukMattej PatritsioRiklen Fab'EnnRoshe Oliv'ETsam Peter

(73)

Holder

F.Khoffmann-Lja Rosh Ag

DIAZEPANE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTORS Russian patent published in 2012 - IPC C07D243/14 C07D401/06 C07D401/14 C07D403/06 C07D405/06 C07D413/12 C07D471/10 A61K31/551 A61P9/10 

Abstract RU 2439065 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel derivatives of diazepane of formula , where A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, n and m have values, given in description and formula of invention, as well as their physiologically acceptable salts. Said compounds are antagonists of chemokine receptors CCR-2, CCR-5 and/or CCR-3 receptor and can be used in medicine as medications.

EFFECT: obtaining novel diazepane derivatives.

20 cl, 505 ex, 4 tbl

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RU 2 439 065 C2

Authors

Ehbi Iogannes

Grin L'Juk

Mattej Patritsio

Riklen Fab'Enn

Roshe Oliv'E

Tsam Peter

Dates

2012-01-10—Published

2007-04-11—Filed

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