3-AZETHIDINYLALKYLPIPERIDINES OR PYRROLIDINES AS TACHYKININE ANTAGONISTS, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF TREATMENT Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel 3-azethidinylalkyl-piperidines or pyrrolidines of the general formula (I) or their pharmaceutically acceptable salts where R means C₃-C₇-cycloalkyl, C₁-C₆-alkyl substituted with C₃-C₇-cycloalkyl or phenyl possibly substituted with OR⁵ where R⁵ means C₁-C₄-alkyl; A means CO or SO₂; R¹ means phenyl substituted with two halide substituents; R² means the group of the formula (II) where R⁵,R⁶,R⁷ mean H; X² means a simple linkage; W means O, NSO₂NR⁵R⁶,NSO₂, (C₁-C₄)-alkyl; n = 1; X¹ means a simple linkage; X means C₁- C₄-alkylene; m = 0 or 1. New compounds are antagonists of tachykinines. Invention describes methods of their synthesis, intermediate compounds, pharmaceutical composition based on thereof and method of treatment of patients. EFFECT: new compounds indicated above, improved method of synthesis, valuable pharmacological properties. 15 cl, 54 ex