METHOD OF PREDICTING ISCHEMIC HEART DISEASE COURSE Russian patent published in 2012 - IPC G01N33/92 

FIELD: medicine.

SUBSTANCE: modified LP (a) are analysed by processing 0.6 ml of blood serum with 0.2 ml of 0.1% Triton X-100 solution, incubation for 15 minutes at 20°C, mixing of mixture by method of shaking for 120 times per min, with further addition of 7% solution of polyethylene glycol 6000 solution and electrophoretic separation in agarose gel in 4x20 mm hollow. If it is determined that level of LP (a) reduces by 35% and more and level of total cholesterol by 20% and more and blood HDLP grows from 13% to 28% and more in comparison with initial level, prediction of disease course is considered to be favourable, contributing to passage of stenocardia of tension FC III-IV into FC I-II. If it is determined that level of modified LP (a) is lower than 35%, total cholesterol - less than 20% and blood HDLP increase to 27% in comparison to initial level, disease prognosis is considered to be unfavourable.

EFFECT: application of method makes it possible to increase accuracy of predicting ischemic heart disease course due to determination of minor fractions of modified blood lipoproteins, determination of blood total cholesterol and HDLP before and after treatment of ischemic heart disease.

6 dwg, 1 tbl, 2 ex