INTRAOCULAR DRUG DELIVERY SYSTEMS Russian patent published in 2012 - IPC A61K9/50 A61K31/505 A61P27/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to medicine, particularly intraocular drug delivery systems. The system contains a number of microsphres of average diameter within 8 micron to 14 micron, an aqueous carrier for microspheres where the microspheres consist of: brimonidine, where brimonidine makes approximately 0.5 wt % to approximately 15 wt % of the microspheres, and one or more biodegradable polymers representing polymer poly(D,L)lactides with inherent viscosity 0.4 dl/g to 0.8 dl/g where PMC polymer makes 85 wt % to 99.5 wt % of the microspheres, and where the drug delivery system can be injected in an intraocular region through a needle of a syringe calibre 20-26, and the microspheres can release approximately 0.5 mcg/day to approximately 20 mcg/day of brimonidine within a period of time approximately 10 days to approximately 100 days to provide treating eye conditions. The intraocular region represents a subtenon space, a subconjunctival or retrobulbar region.

EFFECT: invention provides release of the therapeutic agent in a therapeutically effective amount for a period of 10 days to one year.

4 cl, 13 tbl, 6 dwg, 7 ex