18-METHYL-19-NORANDROST-4-ENE-17,17-SPIROETHER (18-METHYL-19-NOR-20-SPIROX-4-EN-3-ON) AND PHARMACEUTICAL PREPARATIONS CONTAINING SAID COMPOUND Russian patent published in 2012 - IPC C07J53/00 A61K31/58 A61P5/34 A61P5/42 

FIELD: chemistry.

SUBSTANCE: invention describes novel 18-methyl-19-norandrost-4-ene 17,17-spiroethers of general formula 1 in which Z denotes an oxygen atom, R⁴ denotes a hydrogen atom, a chlorine atom, R⁶ and/or R⁷ can have an α or β configuration, and R⁶ and R⁷ independently denote a hydrogen atom or straight or branched alkyl group containing 1-4 or 3-4 carbon atoms, or a straight or branched alkenyl group containing 2-4 or 3-4 carbon atoms, or a saturated cycloalkyl group containing 3-5 carbon atoms, or together denote a methylene group or a double bond.

EFFECT: novel compounds have progestational activity and antimineralocorticoid activity.

2 cl, 20 ex