19,11-BRIDGED OVER 4-ESTRENES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, INTERMEDIATE COMPOUNDS Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the novel 19,11-bridged over 4-estrenes of the general formula (I) where each R^6a and R^6b means hydrogen atom or in common mean methylene group; R⁷ means hydrogen atom; or R^6a means hydrogen atom or fluorine, chlorine, bromine or iodine atom or saturated at α- or β-position alkyl residue with direct or branched chain with amount of C-atoms up to 4; R^6b and R⁷ each means hydrogen atom or in common mean additional bond; or R¹⁴, R¹⁵, R¹⁶ each means hydrogen atom; R¹⁴ means hydrogen atom at α--position; R¹⁵ and R¹⁶ in common mean additional bond or methylene bridge at β-position; or R¹⁶ in common with R^17α mean methylene bridge at α-position and R^17β means the group -C-R²²; or R¹⁶ means hydrogen atom and R¹⁴ and R¹⁵ in common mean additional bond; R¹¹, R^11′ and R¹⁹ each means hydrogen atom; or R¹¹ means hydrogen atom at α-position; and R¹¹ and R¹⁹ in common mean additional bond; or R¹⁹ means hydrogen atom and R¹¹ and R^11′ in common mean additional bond; R^17β/R^17α mean -alkyl or -C-R²²-False or R^17β/R^17α in common mean the formula (II) where x = 1; U = 0; R²¹ means hydrogen atom; R²³ means C₁-C₄-alkyl group; R²² means C₁-C₃-alkyl group' A means hydrogen atom, cyano-group or -OR²⁵ and R²⁵ means hydrogen atom; B means hydrogen atom, C₁-C₄-alkyl group, C₂- or C₃-alkyl group; D means hydrogen atom or hydroxy-group; E and G each means hydrogen atom or C₁-C₃-alkyl; N = 0, 1, 2, 3 or 4; m = 0, 1 or 2; p = 0 or 1; k = 0, 1, 2 or 3; R¹⁶ means hydrogen atom or methyl-group. New compounds show strong gestagenic activity and used for drugs preparing. Invention describes also method of their synthesis, pharmaceutical composition and intermediate compounds. EFFECT: new compounds indicated above, improved method of synthesis and pharmaceutical composition preparing, valuable pharmacological properties. 13 cl, 2 tbl, 1 dwg, 46 ex