FIELD: chemistry.
SUBSTANCE: invention relates to a novel compound - {3,5-dioxo-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-en-4-yl}thiourea of formula I:
, which exhibit antiviral activity towards orthopoxviruses. The compound is obtained through reaction of thiosemicarbazide with 4,4a,5,5a,6,6a-hexahydro-4,6-etheno-1H-cyclopropylisobenzofuran-1,3(3aH)-dione in acetic acid while boiling. Output is equal to 93%.
EFFECT: improved properties of the compound, high yeild.
2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| HYDRATE OF N-{3,5-DIOXO-4-AZATETRACYCLO[5.3.2.0.0]DODEC-11-EN-4-YL}-2-HYDROXYBENZAMIDE, HAVING ANTIVIRAL ACTIVITY TOWARDS ORTHOPOXVIRUSES | 2009 |
|
RU2412168C1 |
| ANTIVIRAL AGENT | 2009 |
|
RU2423359C1 |
| N-{3,5-DIOXO-4-AZATETRACYCLO[5.3.2.0.0]DODEC-11-EN-4-YL}-4-HYDROXYBENZAMIDE, ANTIVIRAL MEDICATION, INHIBITING REPLICATION OF VARIOUS SPECIES OF ORTHOPOXVIRUSES | 2010 |
|
RU2424800C1 |
| 7-[N'-(4-TRIFLUOROMETHYLBENZOLYL)-HYDRAZINOCARBONYL]-TRICYCLO[3.2.2.0]NON-8-ENE-6-CARBOXYLIC ACID, HAVING ANTIVIRAL ACTIVITY | 2009 |
|
RU2412160C1 |
| METHYL, CHLORO AND NITRO-DERIVATIVES OF N-{3, 5-DIOXO-4-AZATETRACYCLO [5.3.2.0.0]DODEC-11-EN-4-YL}-2-HYDROXYBENZAMIDE - ANTIVIRAL AGENTS INHIBITING REPLICATION OF DIFFERENT TYPES OF ORTHOPOXVIRUSES | 2010 |
|
RU2440983C1 |
| MEDICATED PRODUCT FOR SMALLPOX VIRUS AND METHOD FOR PRODUCING AND USING IT | 2013 |
|
RU2543338C1 |
| HYDRAZONES OF AZIDOKETONES OF ALICYCLIC AND ALIPHATIC RANGE, HAVING ANTIVIRAL ACTIVITY | 2007 |
|
RU2376283C2 |
| 1-HYDROXY- AND 1-METHOXY-2-(4-NITROPHENYL)IMIDAZOLE DERIVATIVES WITH ANTIVIRAL ACTIVITY AGAINST ORTHOPOXVIRUSES | 2022 |
|
RU2794763C1 |
| ORAL DOSAGE FORM OF THE PREPARATION IN CAPSULES FOR TREATING AND PREVENTING ORTHOPOXVIRUS-RELATED DISEASES | 2019 |
|
RU2716709C1 |
| N-HETEROCYCLIC BORNYL AMINE DERIVATIVES AS ORTHOPOXVIRUS INHIBITORS | 2018 |
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RU2687254C1 |
