FIELD: medicine, pharmaceutics.
SUBSTANCE: present invention refers to compounds of general formula
where R1 represents halogen, CN or NO2; R2 represents hydrogen or halogen; n is equal to 1 or 2; R3 represents phenyl substituted by one or more halogens or C1-C6 alkyl, or cyclohexyl; as well as to their therapeutically acceptable salts or solvates.
EFFECT: compounds are effective as antagonists of protease activated receptors-1 (PAR-1), especially for treating thrombosis.
19 cl, 4 tbl, 38 ex
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