PHENYLPENTADIENOYL DERIVATIVES AND THEIR APPLICATION AS PAR 1 ANTAGONISTS Russian patent published in 2012 - IPC C07D213/74 C07D295/10 C07D213/61 C07D333/36 A61K31/496 A61P7/00 A61P9/00 

Abstract RU 2440985 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention is related to compounds of general formula (I) where: R1 and R2 either identical or the same represent: hydrogen atom or halogen atom, CN or NO2, with R1 and R2 being other than hydrogen atom simultaneously; m means: 1 or 2, n means: 0, 1 or 2; R3 represents: phenyl radical either substituted or unsubstituted by one or more radical selected halogen atom, hydroxyl group or C1-C6 alkyl group; C2-C6 alkyl group either substituted or unsubstituted by one or more radicals selected from halogen atom or hydroxyl group; cycloalkyl group; pyridine; thiophene; pyrrole either substituted or unsubstituted by C1-C6 alkyl group; thiazole or furan; or to therapeutically acceptable salts or solvates.

EFFECT: invention refers to methods for preparing the compounds of formula I, to based pharmaceutical compositions showing antithrombotic activity, as well as to the use of these compounds for preparing a antiaggregant.

11 cl, 36 ex

Similar patents RU2440985C2

Title Year Author Number
CINNAMOYL-PIPERAZINE DERIVATIVES AND THEIR APPLICATION AS PAR-1 ANTAGONISTS 2007
  • Peres Mishel'
  • Lamot Mari
  • Le Gran Bruno
  • Leht'En Rober
RU2440997C2
SUBSTITUTED PYRAZOLES 2001
  • Brajtenbukher Dzh. Gaj
  • Kaj Kh'Jui
  • Ehdvards Dzhejms P.
  • Grajs Cheril A.
  • Gastin Darin Dzh.
  • Kkhatuja Kharipada
  • Meduna Stiven P.
  • Pajo Barbara A.
  • Tehjs Kevin L.
  • Vej Dzhianmej
RU2286343C2
NEW ARYL - AND HETEROARYLPIPERAZINES 2003
  • Khol'Veg Rol'F
  • Derval'D Florensio Zaragoza
  • Stefensen Khenrik
  • Pettersson Ingrid
  • Peshke Bernd
RU2361869C2
METHOD FOR TREATMENT ALLERGY BY USING SUBSTITUTED PYRAZOLES 2001
  • Brajtenbukher Dzh. Gaj
  • Kaj Kh'Jui
  • Ehdvards Dzhejms P.
  • Grajs Cheril A.
  • Gu Jin
  • Gastin Darin Dzh.
  • Karlsson Lars
  • Kkhatuja Kharipada
  • Meduna Stiven P.
  • Pajo Barbara A.
  • Sun Sikvan
  • Tehjs Kevin L.
  • Termond Robin L.
  • Vej Dzhianmej
RU2277909C2
ARYLSULPHONAMIDE CCR3 ANTAGONISTS 2010
  • Laj Taj Vehj
  • Forrester Dzhared Ehndrju
RU2539591C2
HETEROCYCLIC COMPOUNDS (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD FOR TREATMENT OF DISEASES ASSOCIATED WITH METABOTHROPHIC GLUTAMATE RECEPTORS 2000
  • Van Vagenen Bradford K.
  • Isaak Metvin Bendzhamin
  • Makled Donal'D Eh.
  • Mo Skott T.
  • Slassi Abdel'Malik
  • Smit Dehril L.
  • Stormehnn Tomas M.
  • Shikhehn Suzan M.
RU2296127C9
QUINOXALINES AND AZAQUINOXALINES AS CRTH RECEPTOR MODULATORS 2011
  • Bojs Kristofer V.
  • Degrado Silviya Dzhoanna
  • Chen Syao
  • Tsin Tszyun
  • Matstsola Robert D. Ml.
  • Yuj Yunun
  • Makkormik Kevin D.
  • Palani Anandan
  • Syao Dun
  • Aslanyan Robert Dzhordzh
  • U Tsze
  • Rao Ashvin Umesh
  • Silipkhaivankh Pkhieng
  • Metot Dzhoi Li
  • Chzhan Khuntszyun
  • Kelli Elizabet Khelen
  • Braun Uillyam Kolbi
  • Tszyan Tsin
  • Gouan Kholisiya Polivina
  • Likhejn Endryu Dzh.
  • Bidzhu Purakkattle Dzhoni
  • Dkhondi Pavan K.
  • Dun Li
  • Fevrier Salem
  • Khuan Syankhaj
  • Vakkaro Genri M.
RU2589709C2
DIARYL-SUBSTITUTED 6,5-CONJUGED CYCLIC COMPOUNDS AS C5aR INHIBITORS 2018
  • Fan, Pingchen
  • Lange, Christopher W.
  • Malathong, Viengkham
  • Mali, Venkat Reddy
  • Punna, Sreenivas
  • Tanaka, Hiroko
  • Zeng, Yibin
  • Zhang, Penglie
RU2796983C2
CHROMONE DERIVATIVES, METHOD FOR PREPARING THEM AND THERAPEUTIC USES THEREOF 2010
  • Sokolof P'Er
  • Imber Tierri
  • Lerish Ljudovik
  • Patuaso Zhan-Fransua
  • R'E Zhan-P'Er
RU2545214C2
1,2,4-TRIAZINE-3-AMINE DERIVATIVES 2011
  • Kongriv Majlz Styuart
  • Endryus Stiven Filipp
  • Mejson Dzhonatan Stiven
  • Richardson Kristin Meri
  • Braun Zhajls Albert
RU2771819C2

RU 2 440 985 C2

Authors

Peres Mishel'

Lamot Mari

Le Gran Bruno

Leht'En Rober

Dates

2012-01-27Published

2007-06-19Filed