THERAPEUTIC COMPOUNDS Russian patent published in 2012 - IPC C07H19/16 

FIELD: pharmacology.

SUBSTANCE: invention refers to the compounds with formula (I) And to its pharmaceutically applicable salts, as well as to the use of these compounds as medical products, in particular for treatment of pain or inflammation, and to pharmaceutical compositions on the base of the compounds. In the given formula when X=Y=Z=OH, R₁ is OCH₂CF₂CF₃; phenoxygroup (substituted with 3-(4-trifluormethylphenyl), 3,4-dichlorine, (3-trifluormethyl, 4-fluorine), (3-trifluormethyl, 4-chlorine), (3-chlorine, 4-cyanogroup) or 3,5-bis (trifluormethyl)), 1-piperazinyl-(4-(3,4-dichlorphenyl)); phenyl group substituted with 3,4-dichlorine, 3,5-difluorine, or 3,5-bis(trifluormethyl) or 3,4,5-trifluorine); or 2-benzofuranil fragment; or when X=Y=OH and Z=OMe, R₁ is OCH₃, COH₂CHF₂, OCH₂ cyclopentyl, O-(2,5-difluorphenyl) or (S)-sec-butyl aminogroup; or when X=H and Y=Z=OH, R1 is n-hexylamino- or cyclopentylaminogroup; or when X=Z=OH and Y=H, R1 is cyclopentylaminogroup.

EFFECT: enhanced treatment of pain or inflammation.

25 cl, 23 ex, 21 dwg