BENZIMIDAZOLE DERIVATIVES IN TREATING DISORDERS ASSOCIATED WITH VANILLOID RECEPTOR TRPV1 Russian patent published in 2012 - IPC C07D235/06 C07D409/10 C07D409/12 A61K31/4184 A61P1/04 A61P13/10 A61P19/02 A61P25/00 A61P29/00 

Abstract RU 2458055 C2

FIELD: medicine, pharmaceutics.

SUBSTANCE: there are described new benzimidazole derivatives of general formula I wherein: R1 = CN, halogen or C(=O)CH3; R2 means methyl or H; R3=H or halogen; R4 and R5 independently mean methyl or ethyl, or R4 and R5 together with a carbon atom whereto attached form C3-6cycloalkyl or 5-6-member heterocycloalkyl; R6 and R7 independently mean H, halogen, methyl or ethyl; or their pharmaceutically acceptable salts, pharmaceutical compositions containing these compounds, and their application in therapy.

EFFECT: compounds may be used in treating osteoarthritis, chronic tendinitis, pelvic pain and peripheral neuropathy, gastroesophageal reflux disease, irritable bowel syndrome and overactive bladder.

39 cl, 34 ex

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RU 2 458 055 C2

Authors

Braun Uill'Jam

Dzhonstoun Shon

Labrek Deni

Dates

2012-08-10Published

2007-08-10Filed