FIELD: chemistry.
SUBSTANCE: invention refers to the compound of formula I 
and its prodrug that is represented by 2-(5-(2-((3-(3-tert-butyl-1-p-tolyl-1N-pyrazole-5-yl)ureide)methyl)-4-fluorophenoxy)-1N-indazole-1-yl)ethyl dihydrogen phosphate, and to their pharmaceutically acceptable salts and pharmaceutical compositions based on them. The mentioned compounds are kinase inactivators. The objects of the invention also include the ways of production of the formula I compound, intermediate comppounds for its production and means of treatment of the mammal's condition that is mediated by kinases. In particular, the mentioned compounds can be used in the course of treatment of inflammatory diseases, autoimmune diseases, destructive diseases of bones, proliferative diseases, virulent diseases or neurodegenerative diseases.
EFFECT: compounds that can be used in the course of treatment of inflammatory diseases, autoimmune diseases, destructive diseases of bones, proliferative diseases, virulent diseases or neurodegenerative diseases.
15 cl, 8 tbl, 22 ex
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|---|---|---|---|
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|
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| INDAZOLE COMPOUNDS AS FGFR KINASE INHIBITORS, PREPARATION AND USE THEREOF | 2015 |
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| DERIVATIVES OF 5-MEMBER HETEROCYCLES AS KINASE p38 INHIBITORS | 2004 |
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