WAYS OF PRODUCTION OF ZILPATEROL AND ITS SALTS Russian patent published in 2012 - IPC C07D487/06 C07D235/26 

FIELD: chemistry.

SUBSTANCE: invention refers to the means of production of zilpaterol and its salts including: production of chlorine 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate (or its salt) by means of the method including interaction between 4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)butanoic acid (or its salt) and at least one chlorating agent chosen from the group consisting of oxalyl chloride, phosgene and triphosgene, and production of 8,9-dihydro-2H,7H-2,9a-diabenzo[c,d]azulene-1,6-dione or its salt, by means of the method including interaction between chlorine 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate (or its salt) with the Lewis acid, production of 4,5-dihydro-imidazo[4,5,l-jk][1]benzazepin-2,6,7[1H]-thrion-6-oxime (or its salt) by means of the method including interaction between 8,9-dihydro-2H,7H-2,9a-diazabenzo[cd]azulene-1,6-dione (or its salt) with nonorganic nitrite, production of alkamine salt by means of the method including interaction between 4,5-dihydro-imidazo[4,5,l-jk][1]benzazepin-2,6,7[1H]-thrion-6-oxime (or its salt) with the base and further interacton with H₂ with the presence of hydrogenation catalyst; the alkamine salt corresponds to the structural formula WO-2): and Z denotes a cation, production of izopropilidenamino compound be means of the method including combination of the alkamine salt with acetone and acetic acid; the izopropilidenamino compound structurally corresponds to the formula (WO-1): and production of zilpaterol by interaction between the izopropilidenamino compound (or its salt) and H₂ with the presence of hydrogenation catalyst, with further combination with the base and alcohol, and to the ways of production of intermediate compounds that may be used in productioin of zilpaterol and its salts.

EFFECT: new way of production of zilpaterol and its salt that can be used for acceleration of weight gain, improvement of feed efficiency and/or increase of meagreness of a great cattle, poultry and fish carcass.

12 cl, 9 ex