METHOD OF PRODUCING 3-SUBSTITUTED 2-AMINO-5-HALOBENZAMIDES Russian patent published in 2012 - IPC C07C231/02 C07D401/04 C07C271/28 C07C237/30 C07D265/14 

FIELD: chemistry.

SUBSTANCE: invention discloses a method of producing a compound of formula

through reaction of a compound of formula 2, where R¹ denotes H, C₁-C₄ alkyl, cyclopropyl, cyclopropylmethyl or methylcyclopropyl, R² denotes CH₃ or Cl, and X denotes Cl or Br, with R¹-NH₂ in the presence of a carboxylic acid in an essentially anhydrous reaction medium containing a suitable organic solvent, as well as a method of producing a compound of formula

,

where R² denotes CH₃ or Cl, and X denotes O or Br, involving reaction of a compound of formula

,

where R³ denotes C₁-C₆ alkyl or C₃-C₆ alkenyl, each optionally substituted with not more than 3 halogen atoms and not more than 1 phenyl, with phosphorus tribromide. Also disclosed is a compound 4, where R² denotes CH₃ or Cl; R³ denotes C₁-C₆ alkyl or C₃-C₆ alkenyl, each optionally substituted with not more than 3 halogen atoms and not more than 1 phenyl; and X denotes Cl or Br; provided that when each of R² and X denotes Cl, R³ is not CH₃.

EFFECT: improved method of obtaining the compounds.

12 cl, 6 ex, 4 dwg, 4 tbl