FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing 4-[2-R-2-oxoethyl]-5-nitrobenzene-1,2-dicarboxylic acids of said general formula, where R = C6H5 or 4-CH3C6H4, or 4-OCH3C6H4, or 2-thienyl, which can be used as precursors for synthesis of biologically active substances and drugs. Method comprises heating substituted 4-nitro-5-(2-oxoethyl)phthalonitriles in a solution of sulphuric acid with weight ratio of 75–90 % at a temperature of 100–120 °C for 20–36 hours. After reaction obtained reaction mass is cooled, diluted with ten-fold excess cold water with ice, precipitate of 4-[2-R-2-oxoethyl]-5-nitrobenzene-1,2-dicarboxylic acid is filtered, washed with water, recrystallised from alcohol and dried on air.
EFFECT: proposed method enables to obtain said compounds with sufficient degree of purity.
1 cl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 2-SUBSTITUTED 1-HYDROXY-1H-INDOLE-5,6-DICARBOXYLIC ACIDS | 2015 |
|
RU2613559C1 |
| METHOD OF PRODUCING 5-NITRO-6-(2-OXO-2R-ETHYL)-1H-ISOINDOLE-1,3(2H)-DIONES | 2015 |
|
RU2613560C1 |
| METHOD OF PRODUCING 2-SUBSTITUTED 1-HYDROXYPYRROLO[3,4-ƒ]INDOLE-5,7-(1H,6H)-DIONES | 2015 |
|
RU2613582C1 |
| METHOD OF PRODUCING 1-HYDROXY-3-R-INDOLE-5,6-DICARBONITRILES | 2013 |
|
RU2534988C1 |
| SUBSTITUTED 2-PHENYLINDOLES, SYNTHESIS METHOD THEREOF AND FUNGICIDE COMPOSITIONS BASED ON SAID COMPOUNDS | 2010 |
|
RU2440339C1 |
| METHOD FOR PREPARING 2-(1-ADAMANTYLCARBONYL)-1,2-DIHYDRONAPHTHO [2,1-b] FURANES | 2011 |
|
RU2495033C2 |
| METHOD OF PRODUCING SUBSTITUTED 4-NITRO-5-(2-OXOETHYL)PHTHALONITRILES | 2010 |
|
RU2443681C2 |
| 4,5-BIS-(1',2':3',4'-DI-O-ISOPROPYLIDENE-α-D-GALACTOPYRANOSO-6'-YL)PHTHALONITRILE | 2009 |
|
RU2409585C1 |
| SUBSTITUTED N-[2-(1-ADAMANTYLAMINO)-2-OXOETHYL]-N-(AMINOALKYL)AMIDES OF NITROBENZOIC ACIDS | 2011 |
|
RU2500666C2 |
| NOVEL 4-(AZACYCLOALKYL)PHTHALONITRILES AND SYNTHESIS METHOD THEREOF | 2010 |
|
RU2447061C1 |
