NEUROACTIVE STEROIDS AND METHODS OF USE THEREOF Russian patent published in 2024 - IPC C07J41/00 C07J43/00 A61K31/58 A61K31/57 A61K31/575 A61P25/00 

FIELD: medicine; pharmaceutics.

SUBSTANCE: group of inventions relates to a compound of formula (Il) and specific compounds specified in clause 26, a pharmaceutical composition based thereon for mediating GABA activity, a method of treating a CNS-related disorder associated with GABA activity, and a method of sedation and/or anaesthesia by mediating GABA activity. In general formula (Il) each of R^1a, R^1b, R^2a, R^2b, R^4a, R^4b, R^6a, R^6b, R^7a, R^7b, R^11a, R^11b, R^12a and R^12b is hydrogen; R^3a is ethyl, n-propyl, iso-propyl, n-butyl, cyclopropyl or cyclopropylmethyl; R¹⁸ is methyl; R¹⁹ is hydrogen, methyl or ethyl; R^Y is methyl; each R^D is hydrogen; q is 0, 1, 2, 3, 4 or 5; and R^55a and R^55b are taken with intermediate atoms to form , where p is equal to 1, and R^a is -CN.

EFFECT: neuroactive steroids and methods of using them are disclosed.

58 cl, 3 tbl, 508 ex