ANTITUMORAL COMPOUNDS Russian patent published in 2013 - IPC C07D309/32 C07D309/30 A61K31/351 A61K31/365 A61P35/00 

FIELD: biotechnologies.

SUBSTANCE: invention relates to compounds of general formula I, having cytostatic or cytotoxic activity, its pharmaceutically acceptable salts, tautomers or stereoisomers, a pharmaceutical composition on their basis. Compounds may be used for treatment of cancerous diseases. In the general formula I

Y is selected from the group comprising -CHR_ay- and -CHR_ay-CR_by-CR_cy-; each R_ay, R_by and R_cy are independently selected from hydrogen and non-substitute C₁-C₁₂-alkyl; each R₁, R₂, R₃, R₄ and R₅ are independently selected from hydrogen and non-substitute C₁-C₁₂-alkyl; R₆ is selected from NR₈R₉ and OR₁₀; A means , W means NR₇; R₇ means hydrogen; R₈ means hydrogen; R₁₀ means non-substitute C₂-C₁₂-alkenyl; each dotted line means unnecessary additional link, but when there is a triple link between atoms of carbon, to which R₁ and R₂ are attached, then R₁ and R₂ are absent, and when there is a triple link between carbon atoms, to which R₃ and R₄ are attached, then R₃ and R₄ are absent; R₉ is selected from substitute C₂-C₁₂-alkenyl and substitute C₄-C_|2-alkenylyl, where substitutes are selected from the group, consisting of: halogen, OR', OCONHR' and OH, protected with a simple silyl ether; where R' means hydrogen; provided that whenever Y means -CHR_ay-CR_by=CR_cy- and there is a single or double link between atoms of carbon, to which R₃ and R₄ are attached, then R₉ means substitute C₄-C₁₂-alkenylyl; and each R₁₆, R₁₇ and R₁₈ are independently selected from hydrogen and OR_a; each R_a is selected from hydrogen or non-substitute C₁-C₁₂-alkyl.

EFFECT: higher efficiency of compound application.