ANTITUMOUR COMPOUNDS Russian patent published in 2014 - IPC C07D309/22 A61K31/351 A61P35/00 

FIELD: chemistry.

SUBSTANCE: in general formula (I) Y is -CHR_ay-CHR_by-CHR_cy-; each of R_ay, R_by and R_cy is independently selected from a group consisting of hydrogen and C₁-C₁₂-alkyl; each of R₁, R₂, R₃, R₄ and R₅ is independently selected from a group consisting of hydrogen and unsubstituted C₁-C₁₂-alkyl; R₆ is selected from NR₈R₉; A is a radical (a), W is NR₇; R₇ is hydrogen; R₈ is hydrogen; each dotted line denotes an optional additional bond and one additional bond exists between carbon atoms to which R₁₆ and R₁₇ are bonded; one additional bond exists between carbon atoms to which R₁ and R₂ are bonded, and one additional bond exists between carbon atoms to which R₃ and R₄ are bonded; R₉ is a substituted or unsubstituted C₂-C₁₂-alkenyl, wherein the optional substitutes are selected from a group consisting of a halogen and OR', where each R′ is hydrogen, silyl ethers as a protective group or CONR"R", where each R″ is independently selected form hydrogen and C₁-C₆-alkyl; each of R₁₆, R₁₇ and R₁₈ are independently selected from a group consisting of hydrogen and OR_a; R₁₉ is hydrogen; and R_a is an unsubstituted C₁-C₁₂-alkyl.

EFFECT: high cytotoxic and cytostatic activity.

21 cl, 1 tbl, 24 ex

(a)