ANTITUMOUR COMPOUNDS Russian patent published in 2014 - IPC C07D309/22 A61K31/351 A61P35/00 

Abstract RU 2528393 C9

FIELD: chemistry.

SUBSTANCE: in general formula (I) Y is -CHRay-CHRby-CHRcy-; each of Ray, Rby and Rcy is independently selected from a group consisting of hydrogen and C1-C12-alkyl; each of R1, R2, R3, R4 and R5 is independently selected from a group consisting of hydrogen and unsubstituted C1-C12-alkyl; R6 is selected from NR8R9; A is a radical (a), W is NR7; R7 is hydrogen; R8 is hydrogen; each dotted line denotes an optional additional bond and one additional bond exists between carbon atoms to which R16 and R17 are bonded; one additional bond exists between carbon atoms to which R1 and R2 are bonded, and one additional bond exists between carbon atoms to which R3 and R4 are bonded; R9 is a substituted or unsubstituted C2-C12-alkenyl, wherein the optional substitutes are selected from a group consisting of a halogen and OR', where each R′ is hydrogen, silyl ethers as a protective group or CONR"R", where each R″ is independently selected form hydrogen and C1-C6-alkyl; each of R16, R17 and R18 are independently selected from a group consisting of hydrogen and ORa; R19 is hydrogen; and Ra is an unsubstituted C1-C12-alkyl.

EFFECT: high cytotoxic and cytostatic activity.

21 cl, 1 tbl, 24 ex

(a)

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RU 2 528 393 C9

Authors

Rodriges Visente Al'Berto

Garranso Garsia-Ibarrola Marija

Mursija Peres Karmen

Sanches Sancho Fransisko

Kuehvas Marchante Marija Del' Karmen

Mateo Urbano Kristina

Digon Khuares Isabel'

Dates

2014-09-20Published

2008-12-19Filed