FIELD: medicine, pharmaceutics.
SUBSTANCE: invention relates to medicine and deals with conjugate of three-branched PEG-G-CSF of general formula (1), in which ratio of binding three-branched polyethylene glycol (PEG) and G-CSF constitutes 1:1 (mol/mol), where PEG has molecular weight from 20000 to 45000 Dalton; including its pharmaceutical composition and method of its obtaining.
EFFECT: invention ensures long period of halflife in vivo, increased AUC (area under curve concentration-time) and improved proliferative activity with respect to neutrophils and leukocytes.
9 cl, 14 ex, 11 dwg, 4 tbl
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