PATHOGENIC BACTERIA-INHIBITING BIOLOGICALLY ACTIVE SUBSTANCES AND METHOD OF INHIBITING PATHOGENIC BACTERIA TYPE III SECRETION Russian patent published in 2012 - IPC C07D285/12 C07D285/16 C07D285/36 C07D417/04 C07D417/12 A61K31/431 A61K31/54 A61K31/541 A61K31/551 A61K31/4427 A61P31/04 

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of 1,3,4-thiadiazolines (I), thiadiazinones (II) and thiadiazepines (III), obtained based on thiohydrazides of oxamic acids, which can be used to inhibit pathogenic bacteria, and can particularly affect type III secretion system in pathogens, having general formula:

, , ,

where R denotes H; R¹ denotes H, pyridinyl; phenyl, substituted with alkyl C1-C5, Hal, CF₃; a group , where X denotes S, substituted with alkyl C1-C5, COOR⁴; R², R³ denotes alkyl C1-C5, pyridinyl, phenyl, substituted Hal, OH, OR⁴, a R⁴ denotes unsubstituted alkyl C1-C4.

EFFECT: obtaining compounds which can be used to inhibit pathogenic bacteria.

2 cl, 2 dwg, 6 tbl, 21 ex