N-SUBSTITUTED DERIVATIVES OF OXAMIC ACID THIOHYDRAZIDES, SYNTHESIS METHOD AND USE THEREOF Russian patent published in 2010 - IPC C07C243/18 C07C325/02 C07C327/56 C07D333/38 C07D295/145 C07D213/36 A61K31/5375 A61K31/4402 A61K31/381 A61K31/185 A61P31/04 

Abstract RU 2400471 C1

FIELD: chemistry.

SUBSTANCE: invention relates to N-substituted derivatives of oxamic acid thiohydrazides of general formula: , where R and R1 denote H, unsubstituted or substituted Het, phenyl, Alk, wherein substitutes can be Alk, Hal, CF3, COOR3, SR3, or R+R1=C2H4OC2H4; R2 denotes H, Alk, OR3, Hal, where R3=Alk; Het denotes a 5- or 6-member ring which contains one or two heteroatoms selected from N and S. The invention also relates to a method for synthesis of said compounds.

EFFECT: obtaining novel compounds which exhibit antibacterial activity and can be used as antibacterial agents for inhibiting pathogenic bacteria, including Chlamydia.

4 cl, 21 ex

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RU 2 400 471 C1

Authors

Krajushkin Mikhail Mikhajlovich

Jarovenko Vladimir Nikolaevich

Zajakin Egor Sergeevich

Gintsburg Aleksandr Leonidovich

Zigangirova Nailja Akhatovna

Zorina Viktorija Vladimirovna

Tokarskaja Elizaveta Aleksandrovna

Tartakovskaja Dina Igorevna

Dates

2010-09-27Published

2009-04-30Filed