FIELD: chemistry.
SUBSTANCE: invention relates to novel biologically active compounds of formula 
, where substitutes R, R1, R2 and R3 are defined in the formula of invention, and can be obtained using a method which involves reaction of corresponding chloroacetamides with a prepared solution of elementary sulphur with morpholine or piperidine, passing the obtained solution of monothiooxamides through a layer of sorbent and then reaction of monothiooxamides with hydrazine-hydrate, reaction of the obtained compound with aldehydes in dimethyl formamide at room temperature and precipitation with methanol which gives good output of the end product.
EFFECT: obtained compounds are highly effective against pathogenic bacteria, are characterised by selectivity and can be used to inhibit type III secretion in pathogenic bacteria.
3 cl, 8 dwg, 1 tbl, 21 ex
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